Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50150291 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302338 (CHEMBL828922) |
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Ki | 3.7±n/a nM |
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Citation | Morrissette, MM; Stauffer, KJ; Williams, PD; Lyle, TA; Vacca, JP; Krueger, JA; Lewis, SD; Lucas, BJ; Wong, BK; White, RB; Miller-Stein, C; Lyle, EA; Wallace, AA; Leonard, YM; Welsh, DC; Lynch, JJ; McMasters, DR Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability. Bioorg Med Chem Lett14:4161-4 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50150291 |
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n/a |
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Name | BDBM50150291 |
Synonyms: | (S)-1-((R)-3-Cyclopropyl-2-hydroxy-3-methyl-butyryl)-azetidine-2-carboxylic acid 2-aminomethyl-5-chloro-benzylamide | CHEMBL182124 |
Type | Small organic molecule |
Emp. Form. | C20H28ClN3O3 |
Mol. Mass. | 393.908 |
SMILES | CC(C)([C@@H](O)C(=O)N1CC[C@H]1C(=O)NCc1cc(Cl)ccc1CN)C1CC1 |
Structure |
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