| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM15819 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302605 (CHEMBL838572) |
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| Ki | 77±n/a nM |
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| Citation |  Hooft van Huijsduijnen, R; Sauer, WH; Bombrun, A; Swinnen, D Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs. J Med Chem47:4142-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM15819 |
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| n/a |
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| Name | BDBM15819 |
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| Synonyms: | 1:1 mixture of diastereomers | 2-[(4-{2-[(4-{[(1S)-1-carboxy-3-(methylsulfanyl)propyl]carbamoyl}butyl)carbamoyl]-2-acetamidoethyl}-2-ethylphenyl)amidoformic acid]benzoic acid | CHEMBL55243 | oxalyl-aryl-amino benzoic acid-based inhibitor 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H40N4O10S |
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| Mol. Mass. | 672.746 |
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| SMILES | CCc1cc(CC(NC(C)=O)C(=O)NCCCCC(=O)N[C@@H](CCSC)C(O)=O)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |r| |
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| Structure | 
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