| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 5 |
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| Ligand | BDBM50583237 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2156794 (CHEMBL5041454) |
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| Ki | 2460±n/a nM |
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| Citation |  Szedlacsek, HS; Bajusz, D; Badea, RA; Pop, A; Bic?, CC; Ravasz, L; Mittli, D; Mátyás, D; Necula-Petr?reanu, G; Munteanu, CVA; Papp, I; Juhász, G; Hritcu, L; Keser?, GM; Szedlacsek, SE Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats. J Med Chem65:217-233 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 5 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 5 |
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| Synonyms: | PTN5_HUMAN | PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | Tyrosine-protein phosphatase non-receptor type 5 isoform a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 63510.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_90652859 |
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| Residue: | 565 |
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| Sequence: | MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPP
PPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLV
SSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPED
RRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQ
ERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL
QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR
GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYD
GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
TCEQYQFVHHVMSLYEKQLSHQSPE
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| BDBM50583237 |
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| n/a |
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| Name | BDBM50583237 |
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| Synonyms: | CHEMBL5083791 |
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| Type | Small organic molecule |
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| Emp. Form. | C59H84N13O22P |
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| Mol. Mass. | 1358.3459 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NCC(O)=O |r| |
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| Structure | 
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