| Reaction Details |
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 | Report a problem with these data |
| Target | Neprilysin |
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| Ligand | BDBM50583450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2157371 (CHEMBL5042031) |
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| Ki | 600±n/a nM |
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| Citation |  Arendse, LB; Cozier, GE; Eyermann, CJ; Basarab, GS; Schwager, SL; Chibale, K; Acharya, KR; Sturrock, ED Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J Med Chem65:3371-3387 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neprilysin |
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| Name: | Neprilysin |
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| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85505.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08473 |
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| Residue: | 750 |
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| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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| BDBM50583450 |
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| n/a |
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| Name | BDBM50583450 |
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| Synonyms: | CHEMBL5077796 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N2O6 |
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| Mol. Mass. | 456.5314 |
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| SMILES | CCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r| |
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| Structure | 
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