| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50152907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302721 (CHEMBL839592) |
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| Ki | 754±n/a nM |
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| Citation |  Xue, CB; Chen, XT; He, X; Roderick, J; Corbett, RL; Ghavimi, B; Liu, RQ; Covington, MB; Qian, M; Ribadeneira, MD; Vaddi, K; Trzaskos, J; Newton, RC; Duan, JJ; Decicco, CP Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett14:4453-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50152907 |
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| n/a |
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| Name | BDBM50152907 |
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| Synonyms: | 2-[4-(2-Methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-piperidine-3-carboxylic acid hydroxyamide | CHEMBL184062 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N3O5S |
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| Mol. Mass. | 469.553 |
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| SMILES | Cc1cc(COc2ccc(cc2)S(=O)(=O)CC2NCCCC2C(=O)NO)c2ccccc2n1 |
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| Structure | 
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