| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Ligand | BDBM50033288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161053 (CHEMBL5045803) |
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| IC50 | <25119±n/a nM |
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| Citation |  Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase ? Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem65:3359-3370 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Synonyms: | PI42B_HUMAN | PIP4K2B | PIP5K2B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47382.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774395 |
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| Residue: | 416 |
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| Sequence: | MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV
PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS
VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL
PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD
NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE
RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK
EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
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| BDBM50033288 |
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| n/a |
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| Name | BDBM50033288 |
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| Synonyms: | (2-Phenyl-quinazolin-4-yl)-thiophen-2-ylmethyl-amine | CHEMBL116890 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15N3S |
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| Mol. Mass. | 317.408 |
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| SMILES | C(Nc1nc(nc2ccccc12)-c1ccccc1)c1cccs1 |
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| Structure | 
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