| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
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| Ligand | BDBM50584993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161062 (CHEMBL5045812) |
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| IC50 | 1995±n/a nM |
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| Citation |  Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase ? Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem65:3359-3370 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
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| Synonyms: | PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47302.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774614 |
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| Residue: | 421 |
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| Sequence: | MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN
ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQ
DYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNT
LLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL
KDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEA
PVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAE
GAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIF
A
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| BDBM50584993 |
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| n/a |
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| Name | BDBM50584993 |
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| Synonyms: | CHEMBL5092753 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5 |
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| Mol. Mass. | 343.4249 |
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| SMILES | CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2[nH]ccc2n1 |
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| Structure | 
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