| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type 1B |
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| Ligand | BDBM50585045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2161408 (CHEMBL5046158) |
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| IC50 | 830±n/a nM |
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| Citation |  Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett13:577-585 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type 1B |
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| Name: | Calcium/calmodulin-dependent protein kinase type 1B |
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| Synonyms: | CaM kinase I beta | CaM kinase IB | CaM-KI beta | CaMKI-beta | Calcium/calmodulin-dependent protein kinase type 1B | KCC1B_HUMAN | PNCK | Pregnancy up-regulated non-ubiquitously-expressed CaM kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38501.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109914 |
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| Residue: | 343 |
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| Sequence: | MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVEN
EIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQV
LGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVA
PELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDIS
ESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRA
FNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
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| BDBM50585045 |
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| n/a |
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| Name | BDBM50585045 |
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| Synonyms: | CHEMBL5093741 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19F3N8O |
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| Mol. Mass. | 468.4345 |
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| SMILES | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 |
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| Structure | 
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