| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50585428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2162454 (CHEMBL5047315) |
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| Ki | 8.1±n/a nM |
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| Citation |  Krymov, SK; Scherbakov, AM; Salnikova, DI; Sorokin, DV; Dezhenkova, LG; Ivanov, IV; Vullo, D; De Luca, V; Capasso, C; Supuran, CT; Shchekotikhin, AE Synthesis, biological evaluation, and in silico studies of potential activators of apoptosis and carbonic anhydrase inhibitors on isatin-5-sulfonamide scaffold. Eur J Med Chem228:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50585428 |
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| n/a |
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| Name | BDBM50585428 |
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| Synonyms: | CHEMBL5069716 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11N3O4S |
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| Mol. Mass. | 317.32 |
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| SMILES | NS(=O)(=O)c1ccc2N(Cc3ccncc3)C(=O)C(=O)c2c1 |
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| Structure | 
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