| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50115579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306401 (CHEMBL828742) |
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| IC50 | 25000±n/a nM |
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| Citation |  Maurin, C; Bailly, F; Buisine, E; Vezin, H; Mbemba, G; Mouscadet, JF; Cotelle, P Spectroscopic studies of diketoacids-metal interactions. A probing tool for the pharmacophoric intermetallic distance in the HIV-1 integrase active site. J Med Chem47:5583-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50115579 |
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| n/a |
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| Name | BDBM50115579 |
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| Synonyms: | (Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid (0.25H2O) | CHEMBL16326 | CHEMBL19332 | CHEMBL467389 | Sacchettini_CTRL |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8O4 |
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| Mol. Mass. | 192.1681 |
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| SMILES | OC(=O)C(=O)CC(=O)c1ccccc1 |
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| Structure | 
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