| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 activator 1 |
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| Ligand | BDBM50585764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2163810 (CHEMBL5048671) |
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| IC50 | 1.2±n/a nM |
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| Citation |  Daniels, MH; Malojcic, G; Clugston, SL; Williams, B; Coeffet-Le Gal, M; Pan-Zhou, XR; Venkatachalan, S; Harmange, JC; Ledeboer, M Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem65:3575-3596 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 5 activator 1 |
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| Name: | Cyclin-dependent kinase 5 activator 1 |
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| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 5 |
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| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33308.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 292 |
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| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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| Component 2 |
| Name: | Cyclin-dependent kinase 5 activator 1 |
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| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34077.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15078 |
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| Residue: | 307 |
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| Sequence: | MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
LLLGLDR
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| BDBM50585764 |
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| n/a |
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| Name | BDBM50585764 |
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| Synonyms: | CHEMBL5088315 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30FN5O2 |
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| Mol. Mass. | 487.5685 |
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| SMILES | CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3ccc(cc3F)-c3cccn(C)c3=O)cc2n1 |r| |
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| Structure | 
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