| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-directed RNA polymerase subunit beta |
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| Ligand | BDBM50155485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306640 (CHEMBL832977) |
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| IC50 | 340±n/a nM |
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| Citation |  Doundoulakis, T; Xiang, AX; Lira, R; Agrios, KA; Webber, SE; Sisson, W; Aust, RM; Shah, AM; Showalter, RE; Appleman, JR; Simonsen, KB Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation. Bioorg Med Chem Lett14:5667-72 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-directed RNA polymerase subunit beta |
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| Name: | DNA-directed RNA polymerase subunit beta |
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| Synonyms: | Bacterial DNA-directed RNA polymerase | DNA-directed RNA polymerase beta chain | DNA-directed RNA polymerase subunit beta | RNA polymerase subunit beta | RNA polymerase subunit beta (β-RNAP) | RNAP subunit beta | RPOB_ECOLI | Transcriptase subunit beta | groN | nitB | rif | ron | rpoB | stl | stv | tabD |
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| Type: | Enzyme |
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| Mol. Mass.: | 150595.80 |
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| Organism: | Escherichia coli |
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| Description: | P0A8V2 |
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| Residue: | 1342 |
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| Sequence: | MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQ
SYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQ
EVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYR
GSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQME
LVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKD
YIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRL
SALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGIL
SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLS
LGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTR
ERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVT
DEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQV
VSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKR
GGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERG
DVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS
RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEK
LLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDL
SEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDE
LKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKIN
PIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAK
LREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLK
LGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG
GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMP
ESFNVLLKEIRSLGINIELEDE
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| BDBM50155485 |
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| n/a |
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| Name | BDBM50155485 |
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| Synonyms: | CHEMBL184023 | Myxopyronin B | methyl (E)-5-(5-((2E,4E)-2,5-dimethylnona-2,4-dienoyl)-4-hydroxy-6-oxo-6H-pyran-2-yl)pent-1-enylcarbamate | {(E)-5-[5-((2E,4E)-2,5-Dimethyl-nona-2,4-dienoyl)-4-hydroxy-6-oxo-6H-pyran-2-yl]-pent-1-enyl}-carbamic acid methyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31NO6 |
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| Mol. Mass. | 417.4953 |
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| SMILES | CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(CCCCC=NC(=O)OC)oc1=O |w:22.22,7.6,4.4| |
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| Structure | 
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