| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50155491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302680 (CHEMBL876693) |
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| Ki | 1900±n/a nM |
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| Citation |  Tuthill, PA; Seida, PR; Barker, W; Cassel, JA; Belanger, S; DeHaven, RN; Koblish, M; Gottshall, SL; Little, PJ; DeHaven-Hudkins, DL; Dolle, RE Azepinone as a conformational constraint in the design of kappa-opioid receptor agonists. Bioorg Med Chem Lett14:5693-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM50155491 |
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| n/a |
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| Name | BDBM50155491 |
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| Synonyms: | 1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-[3-(pyrrolidine-1-sulfonyl)-phenyl]-1,3,4,7-tetrahydro-azepin-2-one | CHEMBL185964 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35N3O3S |
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| Mol. Mass. | 493.661 |
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| SMILES | O=C1C(CC=CCN1C(CN1CCCC1)c1ccccc1)c1cccc(c1)S(=O)(=O)N1CCCC1 |c:4| |
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| Structure | 
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