Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCoagulation factor X
LigandBDBM50134404
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305561 (CHEMBL828580)
IC50 5600±n/a nM
Citation Mederski, WW; Cezanne, B; van Amsterdam, C; Bühring, KU; Dorsch, D; Gleitz, J; März, J; Tsaklakidis, C Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett14:5817-22 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50134404
n/a
NameBDBM50134404
Synonyms:(R)-2-[3-(4-Chloro-phenyl)-ureido]-pentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide | (S)-2-[3-(4-Chloro-phenyl)-ureido]-pentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide | CHEMBL122023
TypeSmall organic molecule
Emp. Form.C22H25ClN4O4
Mol. Mass.444.911
SMILESCCC[C@@H](NC(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1)N1CCOCC1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: