| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50155734 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305097 (CHEMBL832401) |
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| IC50 | 45±n/a nM |
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| Citation |  Karageorge, GN; Bertenshaw, S; Iben, L; Xu, C; Sarbin, N; Gentile, A; Dubowchik, GM Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists. Bioorg Med Chem Lett14:5881-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50155734 |
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| n/a |
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| Name | BDBM50155734 |
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| Synonyms: | 1-[1-(2,2-Diphenyl-ethyl)-6,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone | CHEMBL187136 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29NO3 |
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| Mol. Mass. | 415.5241 |
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| SMILES | COc1cc2CCN(C(CC(c3ccccc3)c3ccccc3)c2c(OC)c1)C(C)=O |
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| Structure | 
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