| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 1 |
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| Ligand | BDBM50156331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305666 (CHEMBL827935) |
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| IC50 | 4±n/a nM |
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| Citation |  Luo, G; Mattson, GK; Bruce, MA; Wong, H; Murphy, BJ; Longhi, D; Antal-Zimanyi, I; Poindexter, GS Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists. Bioorg Med Chem Lett14:5975-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 1 |
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| Name: | Neuropeptide Y receptor type 1 |
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| Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44399.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y1 NPY1R HUMAN::P25929 |
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| Residue: | 384 |
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| Sequence: | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
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| BDBM50156331 |
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| n/a |
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| Name | BDBM50156331 |
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| Synonyms: | 2,6-Dimethyl-4-(3-{3-[2-(1-o-tolyl-piperidin-4-ylamino)-ethyl]-ureido}-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | CHEMBL187491 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N5O5 |
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| Mol. Mass. | 575.6984 |
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| SMILES | COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1cccc(NC(=O)NCCNC2CCN(CC2)c2ccccc2C)c1 |c:13,t:10| |
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| Structure | 
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