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TargetP2X purinoceptor 7
LigandBDBM50237707
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2170685 (CHEMBL5055819)
Ki 60±n/a nM
Citation Hopper, ATJuhl, MHornberg, JBadolo, LKilburn, JPThougaard, ASmagin, GSong, DCalice, LMenon, VDale, EZhang, HCajina, MNattini, MEGandhi, AGrenon, MJones, KKhayrullina, TChandrasena, GThomsen, CZorn, SHBrodbeck, RPoda, SBStaal, RMöller, T Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139. J Med Chem64:4891-4902 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 7
Name:P2X purinoceptor 7
Synonyms:P2RX7_MOUSE | P2rx7 | P2x7
Type:PROTEIN
Mol. Mass.:68405.16
Organism:Mus musculus
Description:ChEMBL_1473824
Residue:595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50237707
n/a
NameBDBM50237707
Synonyms:A-804598 | CHEMBL1628690
TypeSmall organic molecule
Emp. Form.C19H17N5
Mol. Mass.315.3718
SMILESC[C@H](N\C(Nc1cccc2ncccc12)=N\C#N)c1ccccc1 |r|
Structure
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