| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/bile acid cotransporter |
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| Ligand | BDBM50157074 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306878 (CHEMBL828684) |
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| IC50 | 300±n/a nM |
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| Citation |  Bhat, L; Jandeleit, B; Dias, TM; Moors, TL; Gallop, MA Synthesis and biological evaluation of novel steroidal pyrazoles as substrates for bile acid transporters. Bioorg Med Chem Lett15:85-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/bile acid cotransporter |
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| Name: | Sodium/bile acid cotransporter |
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| Synonyms: | Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38131.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_838517 |
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| Residue: | 349 |
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| Sequence: | MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
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| BDBM50157074 |
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| n/a |
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| Name | BDBM50157074 |
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| Synonyms: | CHEMBL182671 | {(R)-4-[(4R,10aS,12aR)-4-Hydroxy-8-(3-hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C34H47N3O5 |
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| Mol. Mass. | 577.7541 |
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| SMILES | C[C@H](CCC(=O)NCC(O)=O)C1CCC2C3[C@H](O)CC4Cc5nn(Cc6cccc(O)c6)cc5C[C@]4(C)C3CC[C@]12C |
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| Structure | 
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