| Reaction Details |
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 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Ligand | BDBM50236518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2172731 (CHEMBL5057865) |
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| IC50 | 35±n/a nM |
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| Citation |  Bessho, Y; Akaki, T; Hara, Y; Yamakawa, M; Obika, S; Mori, G; Ubukata, M; Yasue, K; Nakane, Y; Terasako, Y; Orita, T; Doi, S; Iwanaga, T; Fujishima, A; Adachi, T; Ueno, H; Motomura, T Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem52:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 46153.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15119 |
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| Residue: | 407 |
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| Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
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| BDBM50236518 |
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| n/a |
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| Name | BDBM50236518 |
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| Synonyms: | CHEMBL3732469 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20ClN3O3 |
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| Mol. Mass. | 445.898 |
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| SMILES | Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccccc1)C(=O)c1ccc(O)cc1O |
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| Structure | 
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