| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50157657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430067 (CHEMBL918669) |
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| Ki | 2.1±n/a nM |
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| Citation |  Chang, LC; Spanjersberg, RF; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; van den Hout, G; Beukers, MW; Brussee, J; Ijzerman, AP 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem47:6529-40 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM50157657 |
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| n/a |
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| Name | BDBM50157657 |
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| Synonyms: | CHEMBL375631 | cyclopentanecarboxylic acid (2,6-diphenylpyrimidin-4-yl)amide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N3O |
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| Mol. Mass. | 343.4216 |
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| SMILES | O=C(Nc1cc(nc(n1)-c1ccccc1)-c1ccccc1)C1CCCC1 |
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| Structure | 
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