Ki Summary

Reaction Details

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Target

Delta-type opioid receptor

Ligand

BDBM50157686

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_430079 (CHEMBL918101)

0.035±n/a nM

Citation

Balboni, G; Salvadori, S; Dal Piaz, A; Bortolotti, F; Argazzi, R; Negri, L; Lattanzi, R; Bryant, SD; Jinsmaa, Y; Lazarus, LH Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem47:6541-6 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Delta-type opioid receptor

Name:

Delta-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40465.04

Organism:

Rattus norvegicus (rat)

Description:

Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.

Residue:

372

Sequence:

MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA

BDBM50157686

n/a

Name

BDBM50157686

Synonyms:

5-[({5-[(2S)-2-({2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}formamido)-4-carboxybutanamido]pentyl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid | CHEMBL388320

Type

Small organic molecule

Emp. Form.

C52H54N6O11S

Mol. Mass.

971.084

SMILES

Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](CCC(O)=O)C(=O)NCCCCCNC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12 |r,wU:10.11,wD:27.29,(9.42,-23.16,;9.42,-24.7,;8.07,-25.47,;8.07,-27.02,;6.73,-27.79,;9.41,-27.78,;10.75,-27.02,;12.09,-27.79,;10.75,-25.47,;12.09,-24.69,;13.43,-25.47,;13.43,-27.01,;14.77,-24.69,;14.77,-23.15,;16.11,-25.47,;16.11,-27.02,;17.44,-27.79,;17.44,-29.33,;18.77,-30.1,;20.11,-29.33,;20.11,-27.79,;18.77,-27.02,;18.77,-25.47,;17.45,-24.7,;17.45,-23.15,;16.1,-22.38,;18.78,-22.38,;18.78,-20.84,;20.12,-20.06,;21.47,-20.84,;22.8,-20.07,;22.8,-18.53,;24.14,-20.85,;17.45,-20.07,;16.12,-20.84,;17.45,-18.53,;16.12,-17.76,;14.78,-18.53,;13.45,-17.76,;12.12,-18.54,;10.78,-17.77,;9.45,-18.54,;8.11,-17.77,;8.11,-16.23,;6.78,-18.54,;5.45,-17.77,;5.45,-16.24,;4.12,-15.47,;2.79,-16.24,;2.79,-17.79,;4.13,-18.55,;1.69,-18.66,;.4,-18.71,;2.09,-20.17,;1.45,-15.47,;1.45,-13.94,;2.78,-13.18,;2.78,-11.64,;1.44,-10.88,;1.44,-9.34,;.12,-11.64,;.13,-13.17,;-1.21,-13.94,;-1.21,-15.47,;-2.54,-16.23,;-2.55,-17.78,;-3.89,-18.54,;-1.21,-18.55,;.12,-17.8,;.13,-16.25,)|

Structure