Reaction Details |
| Report a problem with these data |
Target | Fibroblast growth factor receptor 1 |
---|
Ligand | BDBM50587619 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2184175 (CHEMBL5096257) |
---|
IC50 | 0.430000±n/a nM |
---|
Citation | Yamani, A; Zd?alik-Bielecka, D; Lipner, J; Sta?czak, A; Piórkowska, N; Sta?czak, PS; Olejkowska, P; Hucz-Kalitowska, J; Magdycz, M; Dzwonek, K; Dubiel, K; Lamparska-Przybysz, M; Popiel, D; Pieczykolan, J; Wieczorek, M Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3). Eur J Med Chem210:0 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Fibroblast growth factor receptor 1 |
---|
Name: | Fibroblast growth factor receptor 1 |
Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr |
Type: | Receptor |
Mol. Mass.: | 91861.70 |
Organism: | Homo sapiens (Human) |
Description: | P11362 |
Residue: | 822 |
Sequence: | MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
|
|
|
BDBM50587619 |
---|
n/a |
---|
Name | BDBM50587619 |
Synonyms: | CHEMBL5205436 |
Type | Small organic molecule |
Emp. Form. | C25H28Cl2N6O2 |
Mol. Mass. | 515.435 |
SMILES | COc1cc(OC)c(Cl)c(CCc2cc(n[nH]2)-c2nc3ccc(cc3[nH]2)N2CCN(C)CC2)c1Cl |
Structure |
|