| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
|---|
| Ligand | BDBM50519624 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2184259 (CHEMBL5096341) |
|---|
| Ki | 0.040000±n/a nM |
|---|
| Citation |  Li, K Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology. Bioorg Med Chem Lett32:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Induced myeloid leukemia cell differentiation protein Mcl-1 |
|---|
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
|---|
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
|---|
| Type: | Membrane; Single-pass membrane protein |
|---|
| Mol. Mass.: | 37332.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07820 |
|---|
| Residue: | 350 |
|---|
| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
|
|
|
|---|
| BDBM50519624 |
|---|
| n/a |
|---|
| Name | BDBM50519624 |
|---|
| Synonyms: | CHEMBL4468645 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H37ClN2O5S |
|---|
| Mol. Mass. | 585.154 |
|---|
| SMILES | [H][C@@]12CC[C@H]1CN1C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc13)C(=O)NS(=O)(=O)[C@H](C)CC\C=C\[C@@H]2O |r,t:42| |
|---|
| Structure | 
|
|---|
Search and Browse
