| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50587813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2185294 (CHEMBL5097376) |
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| IC50 | 63±n/a nM |
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| Citation |  Machulkin, AE; Shafikov, RR; Uspenskaya, AA; Petrov, SA; Ber, AP; Skvortsov, DA; Nimenko, EA; Zyk, NU; Smirnova, GB; Pokrovsky, VS; Abakumov, MA; Saltykova, IV; Akhmirov, RT; Garanina, AS; Polshakov, VI; Saveliev, OY; Ivanenkov, YA; Aladinskaya, AV; Finko, AV; Yamansarov, EU; Krasnovskaya, OO; Erofeev, AS; Gorelkin, PV; Dontsova, OA; Beloglazkina, EK; Zyk, NV; Khazanova, ES; Majouga, AG Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them. J Med Chem64:4532-4552 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84333.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497035 |
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| Residue: | 750 |
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| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM50587813 |
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| n/a |
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| Name | BDBM50587813 |
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| Synonyms: | CHEMBL5206082 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H64ClFN10O12 |
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| Mol. Mass. | 1051.554 |
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| SMILES | OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCN(Cc1ccc(Cl)c(F)c1)C(=O)CCCCCNC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN=[N+]=[N-])C(O)=O)C(O)=O |r| |
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| Structure | 
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