| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor beta |
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| Ligand | BDBM50158412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_430405 (CHEMBL916389) |
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| IC50 | 500000±n/a nM |
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| Citation |  Patel, JB; Huynh, CK; Handratta, VD; Gediya, LK; Brodie, AM; Goloubeva, OG; Clement, OO; Nanne, IP; Soprano, DR; Njar, VC Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. J Med Chem47:6716-29 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor beta |
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| Name: | Retinoic acid receptor beta |
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| Synonyms: | HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50498.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458015 |
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| Residue: | 455 |
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| Sequence: | MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPAT
IETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEM
TAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIV
EFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK
IYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGH
EPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
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| BDBM50158412 |
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| n/a |
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| Name | BDBM50158412 |
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| Synonyms: | CHEMBL388064 | N-(1H-imidazole-1-yl)-(E)-retinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N2O |
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| Mol. Mass. | 350.4971 |
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| SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)n1ccnc1 |c:4| |
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| Structure | 
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