| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin-releasing peptide receptor |
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| Ligand | BDBM50158698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306302 (CHEMBL828594) |
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| IC50 | 0.47±n/a nM |
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| Citation |  Nock, BA; Nikolopoulou, A; Galanis, A; Cordopatis, P; Waser, B; Reubi, JC; Maina, T Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem48:100-10 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin-releasing peptide receptor |
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| Name: | Gastrin-releasing peptide receptor |
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| Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43214.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 2 GRPR 0::P30550 |
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| Residue: | 384 |
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| Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
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| BDBM50158698 |
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| n/a |
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| Name | BDBM50158698 |
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| Synonyms: | CHEMBL266078 | [N40,Pro1,Tyr4]BB |
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| Type | Small organic molecule |
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| Emp. Form. | C83H130N28O19S |
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| Mol. Mass. | 1856.162 |
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| SMILES | CSCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O |
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| Structure | 
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