| Reaction Details |
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 | Report a problem with these data |
| Target | Galactokinase |
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| Ligand | BDBM50588156 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2186388 (CHEMBL5098470) |
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| IC50 | 860±n/a nM |
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| Citation |  Liu, L; Tang, M; Pragani, R; Whitby, FG; Zhang, YQ; Balakrishnan, B; Fang, Y; Karavadhi, S; Tao, D; LeClair, CA; Hall, MD; Marugan, JJ; Boxer, M; Shen, M; Hill, CP; Lai, K; Patnaik, S Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem64:13551-13571 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Galactokinase |
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| Name: | Galactokinase |
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| Synonyms: | GALK | GALK1 | GALK1_HUMAN | Galactokinase | Galactokinase (GALK) | Galactose kinase |
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| Type: | Enzyme |
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| Mol. Mass.: | 42271.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51570 |
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| Residue: | 392 |
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| Sequence: | MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELM
TVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAA
PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGM
PCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRR
RQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDY
RAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASA
APHAMRHIQEHYGGTATFYLSQAADGAKVLCL
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| BDBM50588156 |
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| n/a |
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| Name | BDBM50588156 |
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| Synonyms: | CHEMBL5081119 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H17ClF2N6O4 |
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| Mol. Mass. | 538.89 |
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| SMILES | CC1=C(C(N=C(Nc2nc3ccc(F)cc3o2)N1)c1ccc(F)cc1Cl)C(=O)Nc1cc(ccn1)C(O)=O |t:1,4| |
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| Structure | 
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