| Reaction Details |
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 | Report a problem with these data |
| Target | Corticotropin-releasing factor receptor 2 |
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| Ligand | BDBM50158961 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304279 (CHEMBL829880) |
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| EC50 | 10±n/a nM |
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| Citation |  Isfort, RJ; Wang, F; Tscheiner, M; Donnelly, E; Bauer, MB; Lefever, F; Hinkle, RT; Mazur, AW Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy. J Med Chem48:262-5 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Corticotropin-releasing factor receptor 2 |
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| Name: | Corticotropin-releasing factor receptor 2 |
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| Synonyms: | CRF-R-2 | CRF-R2 | CRF-RB | CRFR-2 | CRFR2_MOUSE | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47628.12 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_51276 |
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| Residue: | 411 |
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| Sequence: | MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIII
AWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
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| BDBM50158961 |
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| n/a |
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| Name | BDBM50158961 |
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| Synonyms: | CHEMBL263862 | Sauvagine derivative |
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| Type | Small organic molecule |
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| Emp. Form. | C208H349N55O61S |
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| Mol. Mass. | 4628.394 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O |
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| Structure | 
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