Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM50588295 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2186646 (CHEMBL5098728) |
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IC50 | 481±n/a nM |
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Citation | Udompholkul, P; Baggio, C; Gambini, L; Alboreggia, G; Pellecchia, M Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein. J Med Chem64:16147-16158 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM50588295 |
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n/a |
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Name | BDBM50588295 |
Synonyms: | CHEMBL5193194 |
Type | Small organic molecule |
Emp. Form. | C34H39FN6O8S |
Mol. Mass. | 710.772 |
SMILES | CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(ccc1OC)S(F)(=O)=O)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| |
Structure |
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