| Reaction Details |
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 | Report a problem with these data |
| Target | Multidrug and toxin extrusion protein 1 |
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| Ligand | BDBM50103595 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187009 (CHEMBL5099091) |
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| IC50 | 2200±n/a nM |
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| Citation |  Shinya, S; Kawai, K; Kobayashi, N; Karuo, Y; Tarui, A; Sato, K; Otsuka, M; Omote, M Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections. Bioorg Med Chem74:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Multidrug and toxin extrusion protein 1 |
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| Name: | Multidrug and toxin extrusion protein 1 |
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| Synonyms: | MATE-1 | MATE1 | S47A1_HUMAN | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61928.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934313 |
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| Residue: | 570 |
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| Sequence: | MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISS
VFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSA
LVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLN
QGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKL
HQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYE
LAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH
VGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVG
LPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNV
PRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRK
QLVLRRGLLLLGVFLILLVGILVRFYVRIQ
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| BDBM50103595 |
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| n/a |
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| Name | BDBM50103595 |
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| Synonyms: | Brumetadina | CHEBI:3699 | Cimetidine | Tagamet | Tagamet HB | Tagamet HB 200 | Valmagen |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16N6S |
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| Mol. Mass. | 252.339 |
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| SMILES | CN\C(NC#N)=N/CCSCc1nc[nH]c1C |
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| Structure | 
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