| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase III subunit alpha |
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| Ligand | BDBM50160356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302895 (CHEMBL830211) |
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| Ki | 47000±n/a nM |
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| Citation |  Wright, GE; Brown, NC; Xu, WC; Long, ZY; Zhi, C; Gambino, JJ; Barnes, MH; Butler, MM Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett15:729-32 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase III subunit alpha |
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| Name: | DNA polymerase III subunit alpha |
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| Synonyms: | DNA polymerase III dnaE | DNA polymerase III subunit alpha | DNA polymerase IIIE | DPO3A_ECOLI | dnaE | polC |
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| Type: | Enzyme |
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| Mol. Mass.: | 129872.84 |
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| Organism: | Escherichia coli |
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| Description: | Enzyme was purified from recombinant strains. |
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| Residue: | 1160 |
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| Sequence: | MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGA
GIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDW
LIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEHFPDRYFLELIRTGRPDEES
YLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
RSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGL
EERLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGP
GRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVAD
MYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQ
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQ
FDKSDVEYAGLVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDML
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREE
ISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
AKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPA
EFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKG
VGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMN
SLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLY
LTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLD
DRSGRLEVMLFTDALDKYQQLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKY
ARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSD
RLLNDLRGLIGSEQVELEFD
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| BDBM50160356 |
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| n/a |
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| Name | BDBM50160356 |
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| Synonyms: | 2-(3,4-Dichloro-benzylamino)-7-(5-methoxy-pentyl)-1,7-dihydro-purin-6-one | CHEMBL181909 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21Cl2N5O2 |
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| Mol. Mass. | 410.298 |
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| SMILES | COCCCCCn1cnc2nc(NCc3ccc(Cl)c(Cl)c3)[nH]c(=O)c12 |
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| Structure | 
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