| Reaction Details |
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 | Report a problem with these data |
| Target | Aspartate aminotransferase, cytoplasmic |
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| Ligand | BDBM81461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2193284 (CHEMBL5105644) |
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| Ki | 14740±n/a nM |
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| Citation |  Wu, Q; Sun, Z; Chen, Z; Liu, J; Ding, H; Luo, C; Wang, M; Du, D The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay. Bioorg Med Chem Lett73:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aspartate aminotransferase, cytoplasmic |
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| Name: | Aspartate aminotransferase, cytoplasmic |
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| Synonyms: | 2.6.1.1 | 2.6.1.3 | AATC_HUMAN | Aspartate aminotransferase, cytoplasmic | Cysteine aminotransferase, cytoplasmic | Cysteine transaminase, cytoplasmic | GOT1 | Glutamate oxaloacetate transaminase 1 | Transaminase A | cAspAT | cCAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46249.45 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_105469 |
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| Residue: | 413 |
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| Sequence: | MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
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| BDBM81461 |
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| n/a |
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| Name | BDBM81461 |
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| Synonyms: | CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NSC_3637 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H8N4 |
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| Mol. Mass. | 160.1759 |
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| SMILES | NNc1nncc2ccccc12 |
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| Structure | 
|
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