| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50589331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2193297 (CHEMBL5105657) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Burns, DM; He, C; Li, YL; Zhuo, J; Qian, DQ; Chen, L; Jalluri, R; Diamond, S; Covington, MB; Li, Y; Wynn, R; Scherle, P; Yeleswaram, S; Hollis, G; Friedman, S; Metcalf, B; Yao, W Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11?-HSD1. Bioorg Med Chem Lett73:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50589331 |
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| n/a |
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| Name | BDBM50589331 |
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| Synonyms: | CHEMBL5182029 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H34N2O2 |
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| Mol. Mass. | 334.4962 |
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| SMILES | O[C@H]1CN(CC2CCCCC2)[C@@]2(CCN(C3CCCCC3)C2=O)C1 |r| |
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| Structure | 
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