Reaction Details |
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Target | Interleukin-1 receptor-associated kinase 4 |
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Ligand | BDBM50589426 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2193539 (CHEMBL5105899) |
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IC50 | 5.0±n/a nM |
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Citation | Chen, Y; Tso, K; Heckrodt, TJ; Li, H; Yen, R; Lin, N; Singh, R; Taylor, V; Masuda, ES; Park, G; Payan, DG Bicyclic pyrimidine compounds as potent IRAK4 inhibitors. Bioorg Med Chem Lett73:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 receptor-associated kinase 4 |
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Name: | Interleukin-1 receptor-associated kinase 4 |
Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
Type: | Protein |
Mol. Mass.: | 51519.08 |
Organism: | Homo sapiens (Human) |
Description: | Q9NWZ3 |
Residue: | 460 |
Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50589426 |
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n/a |
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Name | BDBM50589426 |
Synonyms: | CHEMBL5178272 |
Type | Small organic molecule |
Emp. Form. | C27H28N6O2 |
Mol. Mass. | 468.5502 |
SMILES | [H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2cccc(c2)C(=O)N2CCCC2)nc2ccccc12)C(N)=O |r,c:5| |
Structure |
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