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TargetDual specificity protein kinase CLK1
LigandBDBM293424
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2193619 (CHEMBL5105979)
IC50 8.0±n/a nM
Citation Blackie, AC; Foley, DJ Exploring the roles of the Cdc2-like kinases in cancers. Bioorg Med Chem70:0 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK1
Name:Dual specificity protein kinase CLK1
Synonyms:CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:Protein
Mol. Mass.:57322.21
Organism:Homo sapiens (Human)
Description:P49759
Residue:484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
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  Blast E-value cutoff:
BDBM293424
n/a
NameBDBM293424
Synonyms:US10106527, Compound 10 | US10106527, Compound 142 | US10106527, Compound 143 | US10106527, Compound 144 | US10106527, Compound 459 | US10544128, Compound 144 | US11548872, Compound 459 | US20230286945, Compound 459 | US9951048, Compound 459
TypeSmall organic molecule
Emp. Form.C24H25N7O
Mol. Mass.427.5016
SMILESCN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Structure
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