| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Ligand | BDBM293424 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2193638 (CHEMBL5105998) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Blackie, AC; Foley, DJ Exploring the roles of the Cdc2-like kinases in cancers. Bioorg Med Chem70:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
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| Type: | Enzyme |
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| Mol. Mass.: | 69222.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y463 |
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| Residue: | 629 |
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| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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| BDBM293424 |
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| n/a |
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| Name | BDBM293424 |
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| Synonyms: | US10106527, Compound 10 | US10106527, Compound 142 | US10106527, Compound 143 | US10106527, Compound 144 | US10106527, Compound 459 | US10544128, Compound 144 | US11548872, Compound 459 | US20230286945, Compound 459 | US9951048, Compound 459 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N7O |
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| Mol. Mass. | 427.5016 |
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| SMILES | CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |
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| Structure | 
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