Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50160855 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302478 (CHEMBL827169) |
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Ki | >5000±n/a nM |
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Citation | Kim, SH; Pudzianowski, AT; Leavitt, KJ; Barbosa, J; McDonnell, PA; Metzler, WJ; Rankin, BM; Liu, R; Vaccaro, W; Pitts, W Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett15:1101-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50160855 |
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n/a |
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Name | BDBM50160855 |
Synonyms: | 1-[4-(4-chloro-phenoxy)-phenyl]-1,7,9-triaza-spiro[4.5]decane-2,6,8,10-tetraone | CHEMBL180616 |
Type | Small organic molecule |
Emp. Form. | C19H14ClN3O5 |
Mol. Mass. | 399.785 |
SMILES | Clc1ccc(Oc2ccc(cc2)N2C(=O)CCC22C(=O)NC(=O)NC2=O)cc1 |
Structure |
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