Reaction Details |
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Target | Sodium/potassium-transporting ATPase subunit alpha-1 |
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Ligand | BDBM50161252 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304671 (CHEMBL827871) |
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IC50 | 50000±n/a nM |
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Citation | Van Quaquebeke, E; Simon, G; André, A; Dewelle, J; El Yazidi, M; Bruyneel, F; Tuti, J; Nacoulma, O; Guissou, P; Decaestecker, C; Braekman, JC; Kiss, R; Darro, F Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses. J Med Chem48:849-56 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/potassium-transporting ATPase subunit alpha-1 |
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Name: | Sodium/potassium-transporting ATPase subunit alpha-1 |
Synonyms: | AT1A1_PIG | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain |
Type: | PROTEIN |
Mol. Mass.: | 112664.46 |
Organism: | Sus scrofa |
Description: | ChEMBL_304671 |
Residue: | 1021 |
Sequence: | MGKGVGRDKYEPAAVSEHGDKKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRG
LTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATE
EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINA
EEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNI
AFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFL
GVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWSDNQIHEADTTENQSGVSFDKTSATWLALS
RIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPF
NSTNKYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAY
LELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPLDNLCFVGLISMIDPPRAAVPDA
VGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKA
CVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDS
PASKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTS
NIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTD
KLVNEQLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVNWDDRWINDVEDSY
GQQWTYEQRKIVEFTCHTPFFVTIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEET
ALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETY
Y
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BDBM50161252 |
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n/a |
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Name | BDBM50161252 |
Synonyms: | CHEMBL427124 | Uscharin derivative |
Type | Small organic molecule |
Emp. Form. | C38H60N2O8SSi2 |
Mol. Mass. | 761.128 |
SMILES | C[C@@H]1C[C@]2(SCC(N)=N2)C2(O[Si](C)(C)C)O[C@@H]3C[C@@]4(C=O)[C@@H](CC[C@@H]5[C@@H]4CC[C@]4(C)[C@H](CC[C@]54CO[Si](C)(C)C)C4=CC(=O)OC4)C[C@H]3O[C@@H]2O1 |c:7,t:44| |
Structure |
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