| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50590091 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2194967 (CHEMBL5107327) |
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| Ki | 2930±n/a nM |
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| Citation |  Fernández-Bachiller, MI; Hwang, S; Schembri, ME; Lindemann, P; Guberman, M; Herziger, S; Specker, E; Matter, H; Will, DW; Czech, J; Wagner, M; Bauer, A; Schreuder, H; Ritter, K; Urmann, M; Wehner, V; Sun, H; Nazaré, M Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands. J Med Chem65:13013-13028 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50590091 |
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| n/a |
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| Name | BDBM50590091 |
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| Synonyms: | CHEMBL5202796 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28ClN5O2 |
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| Mol. Mass. | 453.964 |
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| SMILES | CC(C)N1CCC(CC1)NC(=O)c1cn(CC(=O)Nc2ccc(Cl)cc2)c2ncccc12 |
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| Structure | 
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