| Reaction Details |
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 | Report a problem with these data |
| Target | N-acetyltransferase Eis |
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| Ligand | BDBM50017705 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2195999 (CHEMBL5108515) |
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| IC50 | 12200±n/a nM |
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| Citation |  Punetha, A; Green, KD; Garzan, A; Thamban Chandrika, N; Willby, MJ; Pang, AH; Hou, C; Holbrook, SYL; Krieger, K; Posey, JE; Parish, T; Tsodikov, OV; Garneau-Tsodikova, S Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from RSC Med Chem12:1894-1909 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acetyltransferase Eis |
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| Name: | N-acetyltransferase Eis |
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| Synonyms: | Aminoglycoside N-acetyltransferase | EIS_MYCTU | Enhanced intracellular survival protein | N-acetyltransferase Eis | Protein-lysine N-acetyltransferase | eis |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43803.37 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116995 |
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| Residue: | 402 |
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| Sequence: | MTVTLCSPTEDDWPGMFLLAAASFTDFIGPESATAWRTLVPTDGAVVVRDGAGPGSEVVG
MALYMDLRLTVPGEVVLPTAGLSFVAVAPTHRRRGLLRAMCAELHRRIADSGYPVAALHA
SEGGIYGRFGYGPATTLHELTVDRRFARFHADAPGGGLGGSSVRLVRPTEHRGEFEAIYE
RWRQQVPGGLLRPQVLWDELLAECKAAPGGDRESFALLHPDGYALYRVDRTDLKLARVSE
LRAVTADAHCALWRALIGLDSMERISIITHPQDPLPHLLTDTRLARTTWRQDGLWLRIMN
VPAALEARGYAHEVGEFSTVLEVSDGGRFALKIGDGRARCTPTDAAAEIEMDRDVLGSLY
LGAHRASTLAAANRLRTKDSQLLRRLDAAFASDVPVQTAFEF
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| BDBM50017705 |
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| n/a |
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| Name | BDBM50017705 |
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| Synonyms: | 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | 1-{1-[4-(4-Chloro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one(Droperidol) | 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one | 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one | CHEMBL1108 | DROPERIDOL | Inapsine | McN-JR-4749 | R-4749 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22FN3O2 |
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| Mol. Mass. | 379.4274 |
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| SMILES | Fc1ccc(cc1)C(=O)CCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O |c:16| |
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| Structure | 
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