| Reaction Details |
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 | Report a problem with these data |
| Target | MAP/microtubule affinity-regulating kinase 4 |
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| Ligand | BDBM10755 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2196731 (CHEMBL5109247) |
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| IC50 | 2990±n/a nM |
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| Citation |  Shamsi, A; DasGupta, D; Alhumaydhi, FA; Khan, MS; Alsagaby, SA; Al Abdulmonem, W; Hassan, MI; Yadav, DK Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation. RSC Med Chem13:737-745 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP/microtubule affinity-regulating kinase 4 |
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| Name: | MAP/microtubule affinity-regulating kinase 4 |
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| Synonyms: | KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82561.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774620 |
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| Residue: | 752 |
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| Sequence: | MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
AAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPW
SVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLP
RPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
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| BDBM10755 |
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| n/a |
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| Name | BDBM10755 |
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| Synonyms: | 14C-5-hydroxy tryptamine creatinine disulfate | 2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid) | 5-HT | 5-Hydroxy Tryptamine | 5-hydroxy tryptamine creatinine disulfate | CHEMBL535832 | Serotonin | [3H]-5-HT |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12N2O |
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| Mol. Mass. | 176.2151 |
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| SMILES | NCCc1c[nH]c2ccc(O)cc12 |
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| Structure | 
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