Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50049610 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305729 (CHEMBL829401) |
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IC50 | 500±n/a nM |
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Citation | Gangjee, A; Lin, X CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. J Med Chem48:1448-69 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 23891.29 |
Organism: | Pneumocystis carinii |
Description: | n/a |
Residue: | 206 |
Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50049610 |
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n/a |
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Name | BDBM50049610 |
Synonyms: | 6-{[(2,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL54732 |
Type | Small organic molecule |
Emp. Form. | C15H14Cl2N6 |
Mol. Mass. | 349.218 |
SMILES | CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)cc1Cl |
Structure |
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