Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50049609 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305461 (CHEMBL830957) |
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IC50 | 2.7±n/a nM |
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Citation | Gangjee, A; Lin, X CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. J Med Chem48:1448-69 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21638.84 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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BDBM50049609 |
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n/a |
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Name | BDBM50049609 |
Synonyms: | 6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL57624 |
Type | Small organic molecule |
Emp. Form. | C17H20N6O2 |
Mol. Mass. | 340.3797 |
SMILES | COc1ccc(cc1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 |
Structure |
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