| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50033552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305461 (CHEMBL830957) |
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| IC50 | 160±n/a nM |
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| Citation |  Gangjee, A; Lin, X CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. J Med Chem48:1448-69 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50033552 |
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| n/a |
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| Name | BDBM50033552 |
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| Synonyms: | 6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | CHEMBL120826 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N5 |
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| Mol. Mass. | 295.3821 |
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| SMILES | Nc1nc(N)c2CC(CN3CCc4ccccc34)CCc2n1 |
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| Structure | 
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