Reaction Details |
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Target | Phenylethanolamine N-methyltransferase |
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Ligand | BDBM50163104 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303574 (CHEMBL828974) |
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Ki | 61±n/a nM |
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Citation | Grunewald, GL; Romero, FA; Criscione, KR Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. J Med Chem48:1806-12 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phenylethanolamine N-methyltransferase |
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Name: | Phenylethanolamine N-methyltransferase |
Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
Type: | Enzyme |
Mol. Mass.: | 30852.66 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 282 |
Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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BDBM50163104 |
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n/a |
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Name | BDBM50163104 |
Synonyms: | (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (2,2,2-trifluoro-ethyl)-amide | CHEMBL425522 |
Type | Small organic molecule |
Emp. Form. | C12H14F4N2O2S |
Mol. Mass. | 326.31 |
SMILES | FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)NCC(F)(F)F |
Structure |
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