Reaction Details |
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Target | Bifunctional epoxide hydrolase 2 |
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Ligand | BDBM50591344 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2200059 (CHEMBL5112575) |
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IC50 | 0.400000±n/a nM |
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Citation | Codony, S; Entrena, JM; Calvó-Tusell, C; Jora, B; González-Cano, R; Osuna, S; Corpas, R; Morisseau, C; Pérez, B; Barniol-Xicota, M; Griñán-Ferré, C; Pérez, C; Rodríguez-Franco, MI; Martínez, AL; Loza, MI; Pallàs, M; Verhelst, SHL; Sanfeliu, C; Feixas, F; Hammock, BD; Brea, J; Cobos, EJ; Vázquez, S Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem65:13660-13680 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional epoxide hydrolase 2 |
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Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
Type: | Enzyme |
Mol. Mass.: | 62512.06 |
Organism: | Mus musculus (Mouse) |
Description: | P34914 |
Residue: | 554 |
Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
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BDBM50591344 |
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n/a |
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Name | BDBM50591344 |
Synonyms: | CHEMBL5208857 |
Type | Small organic molecule |
Emp. Form. | C27H37N3O3 |
Mol. Mass. | 452.6071 |
SMILES | [2H]C12CC3CC(CC(C1)c1ccccc31)(C2)NC(=O)NC1CCN(CC1)C(=O)C1CCOCC1 |TLB:14:3:7.6.8:15,9:7:3.2.4:15,10:9:6:1.8.15,0:1:6:14.9.3.4,THB:2:3:6:1.8.15,2:1:6:14.9.3.4| |
Structure |
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