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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164121 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 120±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164121 | |||
| n/a | |||
| Name | BDBM50164121 | ||
| Synonyms: | 2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-acetamide | CHEMBL178758 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H17Cl2N5O2 | ||
| Mol. Mass. | 454.309 | ||
| SMILES | Cn1c2nc(Nc3ccc(CC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.5,-3.81,;2.5,-2.27,;1.17,-1.5,;-.18,-2.29,;-1.51,-1.52,;-2.84,-2.29,;-4.17,-1.52,;-5.5,-2.29,;-6.83,-1.55,;-6.83,.02,;-8.17,.79,;-8.18,2.33,;-6.84,3.1,;-9.51,3.07,;-5.5,.79,;-4.17,.02,;-1.51,.02,;-.18,.81,;1.17,.04,;2.48,.81,;3.83,.04,;5.14,.83,;5.14,2.36,;3.79,3.12,;6.46,3.14,;7.8,2.37,;7.82,.83,;6.49,.06,;6.49,-1.48,;3.83,-1.5,;5.16,-2.27,)| | ||
| Structure | 
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