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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164143 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 540±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164143 | |||
| n/a | |||
| Name | BDBM50164143 | ||
| Synonyms: | 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(2,6-dimethyl-phenyl)-5,8-dimethyl-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL180821 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H35N5O2 | ||
| Mol. Mass. | 485.6205 | ||
| SMILES | CCN(CC)CCOc1ccc(Nc2ncc3c(C)c(-c4c(C)cccc4C)c(=O)n(C)c3n2)cc1 |(-9.79,6.13,;-9.79,4.6,;-8.46,3.83,;-7.13,4.6,;-7.13,6.15,;-8.44,2.28,;-7.11,1.53,;-7.11,-.01,;-5.78,-.78,;-4.45,,;-3.1,-.78,;-3.12,-2.31,;-1.77,-3.08,;-.44,-2.31,;-.44,-.75,;.89,,;2.22,-.75,;3.55,.02,;3.53,1.56,;4.88,-.75,;6.21,.04,;6.19,1.56,;4.85,2.33,;7.52,2.35,;8.87,1.59,;8.87,.04,;7.54,-.75,;7.54,-2.27,;4.88,-2.29,;6.23,-3.06,;3.55,-3.06,;3.55,-4.6,;2.22,-2.31,;.89,-3.08,;-4.43,-3.09,;-5.76,-2.33,)| | ||
| Structure | 
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