| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase |
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| Ligand | BDBM50164147 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) |
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| IC50 | >50000±n/a nM |
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| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase |
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| Name: | Wee1-like protein kinase |
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| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71599.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445054 |
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| Residue: | 646 |
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| Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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| BDBM50164147 |
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| n/a |
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| Name | BDBM50164147 |
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| Synonyms: | 5,8-Dimethyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL359732 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4O |
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| Mol. Mass. | 342.3938 |
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| SMILES | Cc1c(-c2ccccc2)c(=O)n(C)c2nc(Nc3ccccc3)ncc12 |
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| Structure | 
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