Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164152 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 1200±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164152 | |||
| n/a | |||
| Name | BDBM50164152 | ||
| Synonyms: | 6-(2,6-Dimethyl-phenyl)-5,8-dimethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL180794 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22N4O | ||
| Mol. Mass. | 370.447 | ||
| SMILES | Cc1cccc(C)c1-c1c(C)c2cnc(Nc3ccccc3)nc2n(C)c1=O |(5.23,-1.24,;5.23,.3,;6.56,1.09,;6.54,2.63,;5.2,3.38,;3.88,2.61,;2.53,3.35,;3.88,1.07,;2.57,.3,;1.22,1.07,;1.22,2.61,;-.09,.27,;-1.42,1.05,;-2.77,.27,;-2.77,-1.27,;-4.1,-2.04,;-5.44,-1.27,;-6.76,-2.06,;-8.09,-1.29,;-8.11,.25,;-6.76,1.04,;-5.41,.27,;-1.42,-2.04,;-.09,-1.27,;1.24,-2.04,;1.24,-3.58,;2.57,-1.24,;3.92,-2.01,)| | ||
| Structure | 
| ||